Identification of genetic loci jointly influencing COVID-19 and coronary heart diseases.

ABSTRACT:

Background

Comorbidities of coronavirus disease 2019 (COVID-19)/coronary heart disease (CHD) pose great threats to disease outcomes, yet little is known about their shared pathology. The study aimed to examine whether comorbidities of COVID-19/CHD involved shared genetic pathology, as well as to clarify the shared genetic variants predisposing risks common to COVID-19 severity and CHD risks.

Methods

By leveraging publicly available summary statistics, we assessed the genetically determined causality between COVID-19 and CHD with bidirectional Mendelian randomization. To further quantify the causality contributed by shared genetic variants, we interrogated their genetic correlation with the linkage disequilibrium score regression method. Bayesian colocalization analysis coupl

SUBMITTER: Wang S 

PROVIDER: S-EPMC10647050 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature