Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway.

ABSTRACT:

Background

The implementation of pyroptosis exhibits significant potential as a tactic to enhance tumor immune microenvironments. Previous applications of pyroptosis inducers have encountered various limitations, such as the development of drug resistance, manifestation of toxic side effects, and a deficiency in targeting capabilities. As a result, there is a growing demand for tumor therapeutic molecules that can overcome these obstacles. Therefore, the objective of this study is to develop a multifunctional nanospheres that addresses these challenges by enabling high-precision targeting of tumor cells and inducing effective pyroptosis.

Results

We prepared a mannose-modified MOF called mannose-doped Fe₃O₄@NH₂-MIL-100 (M-FNM). M-FNM could ent

SUBMITTER: Jin N 

PROVIDER: S-EPMC10647064 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature