ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner.

ABSTRACT:

Background

The establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the development of multiple malignancies. However, its role in hypopharyngeal carcinoma (HPC) progression remains uncharacterized.

Methods

This study employed bioinformatics to determine the ESCO2 expression in head and neck squamous cell carcinoma (HNSC) and normal tissues. In vitro cell proliferation, migration, apoptosis, and/or cell cycle distribution assays were used to determine the function of ESCO2 and its relationship with STAT1. Xenograft models were established in nude mice to determine ESCO2 in HPC growth in vivo. Co-immunoprecipitation/mass spectrometry (Co-IP/MS) was conducted to identify the potential ESCO2 binding partners.

Results

We found that ESCO2

SUBMITTER: Hu J 

PROVIDER: S-EPMC10647066 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature