Nonselective beta-adrenoceptor blocker use and risk of Parkinson's disease: from multiple real-world evidence.

ABSTRACT:

Background

People with hypertension have a higher risk of developing Parkinson's disease (PD), epidemiological evidence suggests that multiple antihypertensives may affect the occurrence and development of PD with inconsistent results. With multisource data, we sought to determine whether specific antihypertensive classes elevated or reduced the risk for PD.

Methods

We used a mixed methods approach that combines 4 methodologies. First, we conducted a disproportionality analysis using the reports causing adverse events in the US Food and Drug Administration Adverse Events Reporting System (FAERS) to explore the effect of different classes of antihypertensive medications on the risk of PD; based on the findings from FAERS, a meta-analysis and a UK Biobank cohort analysis were

SUBMITTER: Feng Z 

PROVIDER: S-EPMC10647086 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature