Bone regeneration property of tooth-derived bone substitute prepared chairside for periodontal bone defects: an experimental study.

ABSTRACT:

Background

Periodontitis often leads to progressive destruction and loss of alveolar bone, the reconstruction of which remains difficult in periodontal therapy. As a novel bone graft material, tooth-derived bone substitute (TDBS) processed from extracted teeth has been previously reported about its osteoconductivity and promising results in bone regeneration. This study was to investigate the biological effects and bone regeneration properties of TDBS in vitro and in vivo using rat periodontal bone defect model.

Methods

Three groups of materials were used in the experiments: TDBS, TDBS treated with ethylene diamine tetraacetic acid (EDTA) (TDBS-E), and allogeneic bone materials. Calcium (Ca) and phosphate (P) ion dissolutions were quantified by spectrophotometer for seven da

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10647160 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature