Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study.

ABSTRACT: IgA nephropathy (IgAN) is an autoimmune disorder which is believed to be non-monogenic. We performed an exome-wide association study of 70 children with IgAN and 637 healthy donors. The HLA allele frequencies were compared between the patients and healthy donors from the bone marrow registry of the Pirogov University. We tested 78,020 gene markers for association and performed functional enrichment analysis and transcription factor binding preference detection. We identified 333 genetic variants, employing three inheritance models. The most significant association with the disorder was observed for rs143409664 (PRAG1) in the case of the additive and dominant models (P_BONF = 1.808 × 10^-15 and P_BONF = 1.654 × 10^-15, respectively), and for rs

SUBMITTER: Buianova AA 

PROVIDER: S-EPMC10647220 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature