Exploring Cell Migration Mechanisms in Cancer: From Wound Healing Assays to Cellular Automata Models.

ABSTRACT:

Purpose

Cell migration is a critical driver of metastatic tumor spread, contributing significantly to cancer-related mortality. Yet, our understanding of the underlying mechanisms remains incomplete.

Methods

In this study, a wound healing assay was employed to investigate cancer cell migratory behavior, with the aim of utilizing migration as a biomarker for invasiveness. To gain a comprehensive understanding of this complex system, we developed a computational model based on cellular automata (CA) and rigorously calibrated and validated it using in vitro data, including both tumoral and non-tumoral cell lines. Harnessing this CA-based framework, extensive numerical experiments were conducted and supported by local and global sensitivity analyses in order to identify the key

SUBMITTER: Migliaccio G 

PROVIDER: S-EPMC10647277 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature