A pH-Sensitive Fluorescent Chemosensor Turn-On Based in a Salen Iron (III) Complex: Synthesis, Photophysical Properties, and Live-Cell Imaging Application.

ABSTRACT: pH regulation is essential to allow normal cell function, and their imbalance is associated with different pathologic situations, including cancer. In this study, we present the synthesis of 2-(((2-aminoethyl)imino)methyl)phenol (HL1) and the iron (III) complex (Fe(L1)₂Br, (C1)), confirmed by X-ray diffraction analysis. The absorption and emission properties of complex C1 were assessed in the presence and absence of different physiologically relevant analytes, finding a fluorescent turn-on when OH^- was added. So, we determined the limit of detection (LOD = 3.97 × 10^-9 M), stoichiometry (1:1), and association constant (K_as = 5.86 × 10³ M^-1). Using DFT calculations, we proposed a spontaneous decomposition mechani

SUBMITTER: Nilo N 

PROVIDER: S-EPMC10647502 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature