Evaluating the Anti-Melanoma Effects and Toxicity of Cinnamaldehyde Analogues.

ABSTRACT: Cinnamaldehyde (CA) showed potent activity against melanoma in our previous study, and the structure of unsaturated aldehydes is envisaged to play a role. Nevertheless, its limited drug availability restricts its clinical application. Therefore, a series of CA analogues were synthesized to evaluate their anti-melanoma activities across various melanoma cell lines. These compounds were also tested for their toxicity against the different normal cell lines. The compound with the most potential, CAD-14, exhibited potent activity against the A375, A875 and SK-MEL-1 cells, with IC₅₀ values of 0.58, 0.65, and 0.82 µM, respectively. A preliminary molecular mechanism study of CAD-14 indicated that it could inhibit the p38 pathway to induce apoptosis, and suppress tumor growth by inhibit

SUBMITTER: Jiang R 

PROVIDER: S-EPMC10647553 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature