Metabolomic Profiling Reveals Differences in Hypoxia Response between Far Eastern and Siberian Frogs.

ABSTRACT: Anoxia is a significant challenge for most animals, as it can lead to tissue damage and death. Among amphibians, the Siberian frog Rana amurensis is the only known species capable of surviving near-zero levels of oxygen in water for a prolonged period. In this study, we aimed to compare metabolomic profiles of the liver, brain, and heart of the Siberian frog exposed to long-term oxygen deprivation (approximately 0.2 mg/L water) with those of the susceptible Far Eastern frog (Rana dybowskii) subjected to short-term hypoxia to the limits of its tolerance. One of the most pronounced features was that the organs of the Far Eastern frog contained more lactate than those of the Siberian frog despite a much shorter exposure time. The amounts of succinate were similar between the two

SUBMITTER: Shekhovtsov SV 

PROVIDER: S-EPMC10647746 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature