From Fruit Waste to Medical Insight: The Comprehensive Role of Watermelon Rind Extract on Renal Adenocarcinoma Cellular and Transcriptomic Dynamics.

ABSTRACT: Cancer researchers are fascinated by the chemistry of diverse natural products that show exciting potential as anticancer agents. In this study, we aimed to investigate the anticancer properties of watermelon rind extract (WRE) by examining its effects on cell proliferation, apoptosis, senescence, and global gene expression in human renal cell adenocarcinoma cells (HRAC-769-P) in vitro. Our metabolome data analysis of WRE exhibited untargeted phyto-constituents and targeted citrulline (22.29 µg/mg). HRAC-769-P cells were cultured in RPMI-1640 media and treated with 22.4, 44.8, 67.2, 88.6, 112, 134.4, and 156.8 mg·mL^-1 for 24, 48, and 72 h. At 24 h after treatment, (88.6 mg·mL^-1 of WRE) cell proliferation significantly reduced, more than 34% compared with the control.

SUBMITTER: Reddy CS 

PROVIDER: S-EPMC10647773 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature