Sigma Receptor Ligands Prevent COVID Mortality In Vivo: Implications for Future Therapeutics.

ABSTRACT: The emergence of lethal coronaviruses follows a periodic pattern which suggests a recurring cycle of outbreaks. It remains uncertain as to when the next lethal coronavirus will emerge, though its eventual emergence appears to be inevitable. New mutations in evolving SARS-CoV-2 variants have provided resistance to current antiviral drugs, monoclonal antibodies, and vaccines, reducing their therapeutic efficacy. This underscores the urgent need to investigate alternative therapeutic approaches. Sigma receptors have been unexpectedly linked to the SARS-CoV-2 life cycle due to the direct antiviral effect of their ligands. Coronavirus-induced cell stress facilitates the formation of an ER-derived complex conducive to its replication. Sigma receptor ligands are believed to prevent the formation

SUBMITTER: Berkowitz RL 

PROVIDER: S-EPMC10647780 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature