The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction.
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ABSTRACT:
SUBMITTER: Clowes SR
PROVIDER: S-EPMC10647805 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction.
Clowes Samuel R SR Ali Yusuf Y Astley Olivia R OR Răsădean Dora M DM Pantoş G Dan GD
Molecules (Basel, Switzerland) 20231027 21
G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were emp ...[more]
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