Clinical-Genomic Risk Group Classification of Suspicious Lesions on Prostate Multiparametric-MRI.

ABSTRACT: The utilization of multi-parametric MRI (mpMRI) in clinical decisions regarding prostate cancer patients' management has recently increased. After biopsy, clinicians can assess risk using National Comprehensive Cancer Network (NCCN) risk stratification schema and commercially available genomic classifiers, such as Decipher. We built radiomics-based models to predict lesions/patients at low risk prior to biopsy based on an established three-tier clinical-genomic classification system. Radiomic features were extracted from regions of positive biopsies and Normally Appearing Tissues (NAT) on T2-weighted and Diffusion-weighted Imaging. Using only clinical information available prior to biopsy, five models for predicting low-risk lesions/patients were evaluated, based on: 1: Clinical variables;

SUBMITTER: Stoyanova R 

PROVIDER: S-EPMC10647832 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature