Dopamine in major depressive disorder: A systematic review and meta-analysis of in vivo imaging studies.

ABSTRACT:

Background

Major depressive disorder (MDD) is a leading cause of global disability. Several lines of evidence implicate the dopamine system in its pathophysiology. However, the magnitude and consistency of the findings are unknown. We address this by systematically reviewing in vivo imaging evidence for dopamine measures in MDD and meta-analysing these where there are sufficient studies.

Methods

Studies investigating the dopaminergic system using positron emission tomography or single photon emission computed tomography in MDD and a control group were included. Demographic, clinical and imaging measures were extracted from each study, and meta-analyses and sensitivity analyses were conducted.

Results

We identified 43 studies including 662 patients and 801 controls. Me

SUBMITTER: Mizuno Y 

PROVIDER: S-EPMC10647912 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature