Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.

ABSTRACT: Glioblastoma is the most common primary brain cancer in adults and represents one of the worst cancer diagnoses for patients. Suffering from a poor prognosis and limited treatment options, tumor recurrences are virtually inevitable. Additionally, treatment resistance is very common for this disease and worsens the prognosis. These and other factors are hypothesized to be largely due to the fact that glioblastoma cells are known to be able to obtain stem-like traits, thereby driving these phenotypes. Recently, we have shown that the in vitro and ex vivo treatment of glioblastoma stem-like cells with the hormonally active form of vitamin D₃, calcitriol (1α,25(OH)₂-vitamin D₃) can block stemness in a subset of cell lines and reduce tumor growth. Here, we expan

SUBMITTER: Rehbein S 

PROVIDER: S-EPMC10648216 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature