Altered plasma protein profiles in genetic FTD - a GENFI study.
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ABSTRACT: Background
Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia.Methods
Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins.Results
We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers.Conclusion
We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process.
SUBMITTER: Ullgren A
PROVIDER: S-EPMC10648335 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
Altered plasma protein profiles in genetic FTD - a GENFI study.
Ullgren Abbe A Öijerstedt Linn L Olofsson Jennie J Bergström Sofia S Remnestål Julia J van Swieten John C JC Jiskoot Lize C LC Seelaar Harro H Borroni Barbara B Sanchez-Valle Raquel R Moreno Fermin F Laforce Robert R Synofzik Matthis M Galimberti Daniela D Rowe James B JB Masellis Mario M Tartaglia Maria Carmela MC Finger Elizabeth E Vandenberghe Rik R de Mendonça Alexandre A Tirabosch Pietro P Santana Isabel I Ducharme Simon S Butler Chris R CR Gerhard Alexander A Otto Markus M Bouzigues Arabella A Russell Lucy L Swift Imogen J IJ Sogorb-Esteve Aitana A Heller Carolin C Rohrer Jonathan D JD Månberg Anna A Nilsson Peter P Graff Caroline C
Molecular neurodegeneration 20231115 1
<h4>Background</h4>Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia.<h4>Methods</h4>Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were a ...[more]
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