Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro.

ABSTRACT: It has long been held as scientific fact that soon after birth, cardiomyocytes cease dividing, thus explaining the limited restoration of cardiac function after a heart attack. Recent demonstrations of cardiac myocyte differentiation observed in vitro or after in vivo transplantation of adult stem cells from blood, fat, skeletal muscle, or heart have challenged this view. Analysis of these studies has been complicated by the large disparity in the magnitude of effects seen by different groups and obscured by the recently appreciated process of in vivo stem-cell fusion. We now show a novel population of nonsatellite cells in adult murine skeletal muscle that progress under standard primary cell-culture conditions to autonomously beating cardiomyocytes. Their differentiation into beating car

SUBMITTER: Winitsky SO 

PROVIDER: S-EPMC1064849 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature