Dataset Information

Perinatal Outcomes at Birth in Women Infected and Non-Infected with SARS-CoV-2: A Retrospective Study.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) was declared as a pandemic and public health emergency on 11 March 2020 by the World Health Organization. Different clinical trials on the efficacy of mRNA vaccination have excluded pregnant women, leading to a lack of empirical evidence on the efficacy of the vaccine in this population. The aim of the study was to examine the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at birth and adverse perinatal outcomes in infected and non-infected women from a university hospital in Spain.

Methods

The data were obtained from electronic health records from 1 March 2020 to 28 February 2022. A bivariate descriptive analysis was performed, comparing women with and without confirmed SARS-CoV-2 infection during pregnancy using the chi-square test. A multivariate logistic regression was complementarily conducted to determine whether SARS-CoV-2 infection increases the risk of adverse obstetric and perinatal outcomes.

Results

A total of 2676 women were divided into two groups: non-infected with SARS-CoV-2 (n = 2624) and infected with SARS-CoV-2 (n = 52). Infected women were primarily multiparous (p < 0.03) and had received an incomplete vaccination regimen (p < 0.001). A greater incidence of premature rupture of membranes (p < 0.04) was observed among the non-infected women. Pertaining to perinatal outcomes, there was a notable rise in NICU admissions (p < 0.014), coupled with an extended duration of stay (p < 0.04), for neonates born to infected mothers in comparison to their non-infected counterparts.

Conclusion

Although SARS-CoV-2 infection may pose significant risks to pregnant women and their infants, adverse obstetrical/puerperal outcomes do not significantly differ between women infected and non-infected to SARS-CoV-2 in our study. NICU admissions were higher for neonates born to infected mothers. Additionally, coronavirus disease 2019 vaccination during pregnancy is not associated with severe adverse perinatal outcomes.

SUBMITTER: Vila-Candel R

PROVIDER: S-EPMC10648606 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

Perinatal Outcomes at Birth in Women Infected and Non-Infected with SARS-CoV-2: A Retrospective Study.

Vila-Candel Rafael R Martin-Arribas Anna A Castro-Sánchez Enrique E Escuriet Ramón R Martin-Moreno Jose M JM

Healthcare (Basel, Switzerland) 20231027 21

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) was declared as a pandemic and public health emergency on 11 March 2020 by the World Health Organization. Different clinical trials on the efficacy of mRNA vaccination have excluded pregnant women, leading to a lack of empirical evidence on the efficacy of the vaccine in this population. The aim of the study was to examine the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at birth and adverse peri ...[more]

PMID: 37957979

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Project description:Globally, ~2.2 billion individuals suffer from visual impairment, with a large proportion of these individuals being women of reproductive age. This demographic often faces unique healthcare challenges, particularly during pregnancy, childbirth and the puerperium. However, despite the significant prevalence of visual impairment among women, there are only a limited number of studies available addressing their specific perinatal care needs. The present study aimed to fill this gap by exploring the perinatal experiences of women who are visually impaired, highlighting the existing care provisions and identifying areas for improvement. For this purpose, a retrospective study was conducted from January to June, 2021, involving 22 women with visual impairment who gave birth after 2005. The study participants were recruited through several organizations supporting individuals who are visually impaired and the participants completed a comprehensive electronic questionnaire designed to be accessible for individuals with visual impairments. The questionnaire covered demographical data, pregnancy, childbirth, puerperium period experiences and interactions with healthcare professionals. The participants included in the present study ranged in age from 29 to >35 years. The origins of their total or partial blindness varied. As shown by the results, ~45.5% of the participants considered they received equivalent levels of midwifery and gynecological care compared to women without visual impairments, and half of the participants reported that midwives and gynecologists were willing to provide such care. However, the majority (90.9%) indicated a lack of adequate knowledge among healthcare providers regarding the specific perinatal care needs of women who are visually impaired. These findings underscore the critical need for the specialized training for healthcare providers and the development of more inclusive, accessible healthcare practices to improve perinatal care for women who are visually impaired.

Project description:BackgroundThe impact of maternal SARS-CoV-2 infection remains unclear. In this study, we evaluated the risk of maternal SARS-CoV-2 infection on birth outcomes and how this is modulated by the pregnancy trimester in which the infection occurs. We also developed models to predict gestational age at delivery for people following a SARS-CoV-2 infection during pregnancy.MethodsWe did a retrospective cohort study of the impact of maternal SARS-CoV-2 infection on birth outcomes. We used clinical data from Providence St Joseph Health electronic health records for pregnant people who delivered in the USA at the Providence, Swedish, or Kadlec sites in Alaska, California, Montana, Oregon, or Washington. The SARS-CoV-2 positive cohort included people who had a positive SARS-CoV-2 PCR-based test during pregnancy, subdivided by trimester of infection. No one in this cohort had been vaccinated for COVID-19 at time of infection. The SARS-CoV-2 negative cohort were people with at least one negative SARS-CoV-2 PCR-based test and no positive tests during pregnancy. Cohorts were matched on common covariates impacting birth outcomes, and univariate and multivariate analysis were done to investigate risk factors and predict outcomes. The primary outcome was gestational age at delivery with annotation of preterm birth classification. We trained multiple supervised learning models on 24 features of the SARS-CoV-2 positive cohort to evaluate performance and feature importance for each model and discuss the impact of SARS-CoV-2 infection on gestational age at delivery.FindingsBetween March 5, 2020, and July 4, 2021, 73 666 pregnant people delivered, 18 335 of whom had at least one SARS-CoV-2 test during pregnancy before Feb 14, 2021. We observed 882 people infected with SARS-CoV-2 during their pregnancy (first trimester n=85; second trimester n=226; and third trimester n=571) and 19 769 people who have never tested positive for SARS-CoV-2 and received at least one negative SARS-CoV-2 test during their pregnancy. SARS-CoV-2 infection indicated an increased risk of preterm delivery (p<0·05) and stillbirth (p<0·05), accounted for primarily by first and second trimester SARS-CoV-2 infections. Gestational age at SARS-CoV-2 infection was correlated with gestational age at delivery (p<0·01) and had the greatest impact on predicting gestational age at delivery. The people in this study had mild or moderate SARS-CoV-2 infections and acute COVID-19 severity was not correlated with gestational age at delivery (p=0·31).InterpretationThese results suggest that pregnant people would benefit from increased monitoring and enhanced prenatal care after first or second trimester SARS-CoV-2 infection, regardless of acute COVID-19 severity.FundingUS National Institutes of Health.

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Dataset Information

Perinatal Outcomes at Birth in Women Infected and Non-Infected with SARS-CoV-2: A Retrospective Study.

Background

Methods

Results

Conclusion

Publications

Perinatal Outcomes at Birth in Women Infected and Non-Infected with SARS-CoV-2: A Retrospective Study.

Similar Datasets

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