COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS.

ABSTRACT:

Background

Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally small, many patients could be affected. However, there is still no data on lung extracellular matrix (ECM) composition in severe COVID-19 and whether it is different from other aetiologies of ARDS.

Methods

We have quantified different ECM elements and TGF-β expression in lung tissue of 28 fatal COVID-19 cases and compared to 27 patients that died of other causes of ARDS, divided according to MV duration (up to six days or seven days or more). In COVID-19 cases, ECM elements were correlated with lung transcriptomics and cytokines profile.

Results

We observ

SUBMITTER: de Souza Xavier Costa N 

PROVIDER: S-EPMC10648646 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature