DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis.

ABSTRACT: Arsenic is a known human urinary bladder carcinogen. While arsenic is known to cause aberrant DNA methylation, the mechanism of arsenic-triggered bladder carcinogenesis is not fully understood. The goal of this study was to identify aberrant DNA methylation in rat bladder urothelial carcinoma (UC) induced by dimethylarsinic acid (DMA^V), a major organic metabolite of arsenic. We performed genome-wide DNA methylation and microarray gene expression analyses of DMA^V-induced rat UCs and the urothelium of rats treated for 4 weeks with DMA^V. We identified 40 genes that were both hypermethylated and downregulated in DMA^V-induced rat UCs. Notably, four genes (CPXM1, OPCML, TBX20, and KCND3) also showed reduced expression in the bladder urothelium after 4

SUBMITTER: Yamamoto T 

PROVIDER: S-EPMC10648661 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature