Incidence and prevalence of congenital clubfoot in Apulia: a regional model for future prospective national studies.

ABSTRACT:

Background

Congenital clubfoot is a fairly common and severe congenital malformation, most often of idiopathic origin. A smaller percentage of cases is related to chromosomal abnormalities and genetic syndromes. It is estimated that 0.5/1000 newborns are affected worldwide, with a male to female ratio of 2:1 and greater distribution in developing countries (80%). The "European Surveillance of Congenital Anomalies (EUROCAT)" reported clubfoot prevalence in European newborns, but data regarding Italy are missing or poor. We aim to provide detailed data on clubfoot incidence according to the Apulian Regional Registry on Congenital Malformations and to report current knowledge on clubfoot genetic factors.

Methods

We extrapolated data from the Regional Registry of Congenital Malf

SUBMITTER: Panza R 

PROVIDER: S-EPMC10648723 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature