Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis.

ABSTRACT: Experimental arthritis models are considered valuable tools for delineating mechanisms of inflammation and autoimmune phenomena. Use of microarray-based methods represents a new and challenging approach that allows molecular dissection of complex autoimmune diseases such as arthritis. In order to characterize the temporal gene expression profile in joints from the reactivation model of streptococcal cell wall (SCW)-induced arthritis in Lewis (LEW/N) rats, total RNA was extracted from ankle joints from naive, SCW injected, or phosphate buffered saline injected animals (time course study) and gene expression was analyzed using Affymetrix oligonucleotide microarray technology (RAE230A). After normalization and statistical analysis of data, 631 differentially expressed genes were sorted into c

SUBMITTER: Rioja I 

PROVIDER: S-EPMC1064886 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature