Population pharmacokinetic model of cefepime for critically ill adults: a comparative assessment of eGFR equations.

ABSTRACT: Cefepime exhibits highly variable pharmacokinetics in critically ill patients. The purpose of this study was to develop and qualify a population pharmacokinetic model for use in the critically ill and investigate the impact of various estimated glomerular filtration rate (eGFR) equations using creatinine, cystatin C, or both on model parameters. This was a prospective study of critically ill adults hospitalized at an academic medical center treated with intravenous cefepime. Individuals with acute kidney injury or on kidney replacement therapy or extracorporeal membrane oxygenation were excluded. A nonlinear mixed-effects population pharmacokinetic model was developed using data collected from 2018 to 2022. The 120 included individuals contributed 379 serum samples for analysis. A two-comp

SUBMITTER: Barreto EF 

PROVIDER: S-EPMC10648925 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature