Octopamine Rescues Endurance and Climbing Speed in Drosophila Clk^out Mutants with Circadian Rhythm Disruption.

ABSTRACT: Circadian rhythm disturbances are associated with various negative health outcomes, including an increasing incidence of chronic diseases with high societal costs. While exercise can protect against the negative effects of rhythm disruption, it is not available to all those impacted by sleep disruptions, in part because sleep disruption itself reduces exercise capacity. Thus, there is a need for therapeutics that bring the benefits of exercise to this population. Here, we investigate the relationship between exercise and circadian disturbances using a well-established Drosophila model of circadian rhythm loss, the Clk^out mutant. We find that Clk^out causes reduced exercise capacity, measured as post-training endurance, flight performance, and climb

SUBMITTER: Safdar M 

PROVIDER: S-EPMC10648926 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature