Unexpectedly low drug exposures among Ugandan patients with TB and HIV receiving high-dose rifampicin.
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ABSTRACT:
SUBMITTER: Kengo A
PROVIDER: S-EPMC10649026 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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Unexpectedly low drug exposures among Ugandan patients with TB and HIV receiving high-dose rifampicin.
Kengo Allan A Gausi Kamunkhwala K Nabisere Ruth R Musaazi Joseph J Buzibye Allan A Omali Denis D Aarnoutse Rob R Lamorde Mohammed M Dooley Kelly E KE Sloan Derek James DJ Sekaggya-Wiltshire Christine C Denti Paolo P
Antimicrobial agents and chemotherapy 20231018 11
We characterized the pharmacokinetics of standard- and high-dose rifampicin in Ugandan adults with tuberculosis and HIV taking dolutegravir- or efavirenz-based antiretroviral therapy. A liver model with saturable hepatic extraction adequately described the data, and the increase in exposure between high and standard doses was 4.7-fold. This was lower than what previous reports of dose-exposure nonlinearity would predict and was ascribed to 38% lower bioavailability of the rifampicin-only top-up ...[more]
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