Structural Analysis and Characterization of an Antiproliferative Lectin from Canavalia villosa Seeds.

ABSTRACT: Cells use glycans to encode information that modulates processes ranging from cell-cell recognition to programmed cell death. This information is encoded within a glycocode, and its decoding is performed by carbohydrate-binding proteins. Among these, lectins stand out due to their specific and reversible interaction with carbohydrates. Changes in glycosylation patterns are observed in several pathologies, including cancer, where abnormal glycans are found on the surfaces of affected tissues. Given the importance of the bioprospection of promising biomolecules, the current work aimed to determine the structural properties and anticancer potential of the mannose-specific lectin from seeds of Canavalia villosa (Cvill). Experimental elucidation of the primary and 3D structures of the le

SUBMITTER: Lossio CF 

PROVIDER: S-EPMC10649158 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature