JAK3 Inhibition Regulates Stemness and Thereby Controls Glioblastoma Pathogenesis.

ABSTRACT: Glioblastoma multiforme (GBM) is the most deadly brain tumor, effective treatment options for which still remain elusive. The current treatment procedure of maximal resection followed by chemotherapy has proved to be grossly insufficient to prevent disease progression and death. Despite best efforts, the maximum survival post-diagnosis is a mere 1.5 years. Therefore, there is a huge unmet clinical need to find effective therapeutic procedures to prevent the pathogenesis and relapse of GBM. Small-molecule inhibitors of signaling pathways are an attractive option to prevent various types of tumors. However, no effective small-molecule inhibitors have been successful against GBM in clinical trials. Various signaling pathways are altered and an array of signaling molecules, transcription facto

SUBMITTER: Smedley W 

PROVIDER: S-EPMC10649349 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature