Increased Gene Expression of C1orf74 Is Associated with Poor Prognosis in Cervical Cancer.

ABSTRACT: C1orf74, also known as URCL4, has been reported to have higher expression and be associated with poor prognosis in lung adenocarcinoma patients, and its role in regulation of the EGFR/AKT/mTORC1 pathway has been recently elucidated. In the current study, we used publicly available data and experimental validation of C1orf74 gene expression and its association with prognosis in cervical cancer patients. qRT-PCR was performed using RNA from cervical cancer cell lines and twenty-five cervical cancer patients. Data from TNMplot revealed that mRNA expression of the C1orf74 gene in primary tumor tissues, as well as metastatic tissues from cervical cancer patients, was significantly higher compared to normal cervical tissues. HPV-positive tumors had higher expression of this

SUBMITTER: Parida P 

PROVIDER: S-EPMC10649411 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature