Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice.

ABSTRACT:

Background

Despite the promising efficacy of immune checkpoint blockers (ICB), tumor resistance and immune-related adverse events hinder their success in cancer treatment. To address these challenges, intratumoral delivery of immunotherapies has emerged as a potential solution, aiming to mitigate side effects through reduced systemic exposure while increasing effectiveness by enhancing local bioavailability. However, a comprehensive understanding of the local and systemic distribution of ICBs following intratumoral administration, as well as their impact on distant tumors, remains crucial for optimizing their therapeutic potential.To comprehensively investigate the distribution patterns following the intratumoral and intravenous administration of radiolabeled anti-cytotoxic T-lymph

SUBMITTER: Meyblum L 

PROVIDER: S-EPMC10649793 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature