Comprehensive analyses of immune tumor microenvironment in papillary renal cell carcinoma.

ABSTRACT:

Background

Papillary renal cell carcinoma (pRCC) is the most common non-clear cell RCC, and associated with poor outcomes in the metastatic setting. In this study, we aimed to comprehensively evaluate the immune tumor microenvironment (TME), largely unknown, of patients with metastatic pRCC and identify potential therapeutic targets.

Methods

We performed quantitative gene expression analysis of TME using Microenvironment Cell Populations-counter (MCP-counter) methodology, on two independent cohorts of localized pRCC (n=271 and n=98). We then characterized the TME, using immunohistochemistry (n=38) and RNA-sequencing (RNA-seq) (n=30) on metastatic pRCC from the prospective AXIPAP trial cohort.

Results

Unsupervised clustering identified two "TME subtypes", in each of th

SUBMITTER: de Vries-Brilland M 

PROVIDER: S-EPMC10649801 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature