Unknown

Dataset Information

0

Effects of Catecholamine Stress Hormones Norepinephrine and Epinephrine on Growth, Antimicrobial Susceptibility, Biofilm Formation, and Gene Expressions of Enterotoxigenic Escherichia coli.


ABSTRACT: Enterotoxigenic Escherichia coli (ETEC) is a significant contributor to diarrhea. To determine whether ETEC-catecholamine hormone interactions contribute to the development of diarrhea, we tested the effects of catecholamine hormones acting on ETEC in vitro. The results showed that in the presence of norepinephrine (NE) and epinephrine (Epi), the growth of 9 out of 10 ETEC isolates was promoted, the MICs of more than 60% of the isolates to 6 antibiotics significantly increased, and the biofilm formation ability of 10 ETEC isolates was also promoted. In addition, NE and Epi also significantly upregulated the expression of the virulence genes feaG, estA, estB, and elt. Transcriptome analysis revealed that the expression of 290 genes was affected by NE. These data demonstrated that catecholamine hormones may augment the diarrhea caused by ETEC.

SUBMITTER: Niu L 

PROVIDER: S-EPMC10649963 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Effects of Catecholamine Stress Hormones Norepinephrine and Epinephrine on Growth, Antimicrobial Susceptibility, Biofilm Formation, and Gene Expressions of Enterotoxigenic <i>Escherichia coli</i>.

Niu Lingdi L   Gao Mingchun M   Wen Shanshan S   Wang Fang F   Shangguan Haikun H   Guo Zhiyuan Z   Zhang Runxiang R   Ge Junwei J  

International journal of molecular sciences 20231027 21


Enterotoxigenic <i>Escherichia coli</i> (ETEC) is a significant contributor to diarrhea. To determine whether ETEC-catecholamine hormone interactions contribute to the development of diarrhea, we tested the effects of catecholamine hormones acting on ETEC in vitro. The results showed that in the presence of norepinephrine (NE) and epinephrine (Epi), the growth of 9 out of 10 ETEC isolates was promoted, the MICs of more than 60% of the isolates to 6 antibiotics significantly increased, and the bi  ...[more]

Similar Datasets

| S-EPMC4652048 | biostudies-literature
| S-EPMC7560392 | biostudies-literature
| S-EPMC3303991 | biostudies-literature
| S-EPMC7922341 | biostudies-literature
| S-EPMC1951185 | biostudies-literature
| S-EPMC4529162 | biostudies-literature
| S-EPMC7396564 | biostudies-literature
| S-EPMC8581654 | biostudies-literature
| S-EPMC7325280 | biostudies-literature
| S-EPMC6451296 | biostudies-literature