Collagen-Coated Hyperelastic Bone Promotes Osteoblast Adhesion and Proliferation.

ABSTRACT: Successfully reconstructing bone and restoring its dynamic function represents a significant challenge for medicine. Critical size defects (CSDs), resulting from trauma, tumor removal, or degenerative conditions, do not naturally heal and often require complex bone grafting. However, these grafts carry risks, such as tissue rejection, infections, and surgical site damage, necessitating the development of alternative treatments. Three-dimensional and four-dimensional printed synthetic biomaterials represent a viable alternative, as they carry low production costs and are highly reproducible. Hyperelastic bone (HB), a biocompatible synthetic polymer consisting of 90% hydroxyapatite and 10% poly(lactic-co-glycolic acid, PLGA), was examined for its potential to support cell adhesion, migration

SUBMITTER: Gresita A 

PROVIDER: S-EPMC10649997 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature