The Antioxidant and Immunomodulatory Potential of Coccoloba alnifolia Leaf Extracts.

ABSTRACT: Oxidative stress has been associated with different diseases, and different medicinal plants have been used to treat or prevent this condition. The leaf ethanolic extract (EE) and aqueous extract (AE) from Coccoloba alnifolia have previously been characterized to have antioxidant potential in vitro and in vivo. In this study, we worked with EE and AE and two partition phases, AF (ethyl acetate) and BF (butanol), from AE extract. These extracts and partition phases did not display cytotoxicity. The EE and AE reduced NO production and ROS in all three concentrations tested. Furthermore, it was observed that EE and AE at 500 μg/mL concentration were able to reduce phagocytic activity by 30 and 50%, respectively. A scratch assay using a fibroblast cell line (NHI/3T3) showed that extract

SUBMITTER: de Melo LFM 

PROVIDER: S-EPMC10650087 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature