GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina.

ABSTRACT: Using constitutive GRF1/2 knockout mice, we showed previously that GRF2 is a key regulator of nuclear migration in retinal cone photoreceptors. To evaluate the functional relevance of that cellular process for two putative targets of the GEF activity of GRF2 (RAC1 and CDC42), here we compared the structural and functional retinal phenotypes resulting from conditional targeting of RAC1 or CDC42 in the cone photoreceptors of constitutive GRF2^KO and GRF2^WT mice. We observed that single RAC1 disruption did not cause any obvious morphological or physiological changes in the retinas of GRF2^WT mice, and did not modify either the phenotypic alterations previously described in the retinal photoreceptor layer of GRF2^KO mice. In contrast, the single ablatio

SUBMITTER: Jimeno D 

PROVIDER: S-EPMC10650203 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature