Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies.

ABSTRACT: Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-auto

SUBMITTER: Zarrabi A 

PROVIDER: S-EPMC10650215 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature