Novel styryl-thiazole hybrids as potential anti-Alzheimer's agents.

ABSTRACT: In this study, combining the thiazole and cinnamoyl groups into the styryl-thiazole scaffold, a series of novel styryl-thiazole hybrids (6a-p) was rationally designed, synthesized, and evaluated by the multi-target-directed ligands strategy as potential candidates for the treatment of Alzheimer's disease (AD). Hybrids 6e and 6i are the most promising among the synthesized hybrids since they are able to significantly increase cell viabilities in Aβ_1-42-exposed-human neuroblastoma cell line (6i at the concentration of 50 μg mL^-1 and 6e at the concentration of 25 μg mL^-1 resulted in ∼34% and ∼30% increase in cell viabilities, respectively). Compounds 6e and 6i exhibit highly AChE inhibitory properties in the experimental AD model at 375.6 ± 18.425 mU mL^-1

SUBMITTER: Gouleni N 

PROVIDER: S-EPMC10650344 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature