The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review.

ABSTRACT: Diabetic retinopathy (DR) is renowned as a leading cause of visual loss in working-age populations with its etiopathology influenced by the disturbance of biochemical metabolic pathways and genetic factors, including gene polymorphism. Metabolic pathways considered to have an impact on the development of the disease, as well as genes and polymorphisms that can affect the gene expression, modify the quantity and quality of the encoded product (protein), and significantly alter the metabolic pathway and its control, and thus cause changes in the functioning of metabolic pathways. In this article, the screening of chromosomes and the most important genes involved in the etiology of diabetic retinopathy is presented. The common databases with manuscripts published from January 2000 to June 202

SUBMITTER: Sienkiewicz-Szlapka E 

PROVIDER: S-EPMC10650381 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature