The Enolase of the Haemophilus influenzae Mediates Binding to Collagens: An Extracellular Matrix Component.

ABSTRACT: Enolase proteins play a significant role as moonlighting proteins. In their role as surface-associated enolase, they have multiple functions as they interact with extracellular matrix proteins. Type I and III collagens are the major constituents of this extracellular matrix, and collagen is one of the targets of interaction with the enolase of many pathogens, thereby helping the colonization process and promoting the subsequent invasion of the host. This work aimed to determine the participation of non-typeable H. influenzae enolase as a collagen-binding protein. In this study, through the use of in vitro tests it was demonstrated that recombinant enolase of non-typeable H. influenzae (rNTHiENO) strongly binds to type I collagen. Using molecular docking, the residues that cou

SUBMITTER: Osorio-Aguilar Y 

PROVIDER: S-EPMC10650631 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature