Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish.

ABSTRACT: Cataract is the leading cause of blindness worldwide. It can be treated by surgery, whereby the damaged crystalline lens is replaced by a synthetic lens. Although cataract surgery is highly effective, a relatively common complication named posterior capsular opacification (PCO) leads to secondary loss of vision. PCO is caused by abnormal proliferation and migration of residual lens epithelial cells (LECs) that were not removed during the surgery, which results in interruption to the passage of light. Despite technical improvements to the surgery, this complication has not been eradicated. Efforts are being made to identify drugs that can be applied post-surgery, to inhibit PCO development. Towards the goal of identifying such drugs, we used zebrafish embryos homozygous for a mutation in

SUBMITTER: Taler K 

PROVIDER: S-EPMC10650733 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature