Effect of menthol on nicotine reduction: Pooled results from two double-blind randomized controlled trials.

ABSTRACT:

Background

Menthol upregulates nicotinic acetylcholine receptors and is associated with tobacco dependence. The effects of menthol when smoking cigarettes with varying low nicotine content up to 98 % (e.g., non-addicting) less than commercial cigarettes is not well understood. The U.S. Food and Drug Administration is considering two tobacco product standards in cigarettes including banning menthol and reducing nicotine content. These new standards have the potential to significantly reduce smoking initiation and maintenance by limiting the mechanistic effects of nicotine and menthol on the brain.

Methods

We conducted two parallel randomized clinical trials of gradually reduced nicotine in cigarettes from 11.6 mg down to 0.2 mg nicotine/cigarette (very low nicotine content; V

SUBMITTER: Lin W 

PROVIDER: S-EPMC10650975 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature