Maternal blood transcriptome as a sensor of fetal organ maturation at the end of organogenesis in cattle†.

ABSTRACT: Harnessing information from the maternal blood to predict fetal growth is attractive yet scarcely explored in livestock. The objectives were to determine the transcriptomic modifications in maternal blood and fetal liver, gonads, and heart according to fetal weight and to model a molecular signature based on the fetal organs allowing the prediction of fetal weight from the maternal blood transcriptome in cattle. In addition to a contemporaneous maternal blood sample, organ samples were collected from 10 male fetuses at 42 days of gestation for RNA-sequencing. Fetal weight ranged from 1.25 to 1.69 g (mean = 1.44 ± 0.15 g). Clustering data analysis revealed clusters of co-expressed genes positively correlated with fetal weight and enriching ontological terms biologically relevant for the org

SUBMITTER: Rabaglino MB 

PROVIDER: S-EPMC10651065 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature