Maternal cafeteria diet and reproductive functions in offspring.

ABSTRACT: Kisspeptin (KP, encoded by Kiss1, binding to the Gpr54 receptor) is a neuropeptide conveying information on the metabolic status to the hypothalamic-pituitary-gonadal (HPG) axis. KP acts together with dynorphin A (DYN A, encoded by Pdyn) and neurokinin B (NKB, encoded by Tac2) to regulate reproduction. Moreover, KP is crucial for the onset of puberty and is under the control of sirtuin (encoded by Sirt1). We hypothesize that the maternal cafeteria (CAF) diet has adverse effects on the offspring's hormonal, metabolic and reproductive functions due to sex-specific alterations in the expression of Kiss1, Gpr54, Pdyn, Tac2, and Sirt1 in the hypothalamus, and Kiss1, Gpr54, Sirt1 in the liver. Rats were fed a CAF diet before pregnancy, during pregnancy and lactation. The vaginal opening was moni

SUBMITTER: Matuszewska J 

PROVIDER: S-EPMC10651067 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature