Listeria monocytogenes infection in pregnant macaques alters the maternal gut microbiome†.

ABSTRACT:

Objectives

The bacterium Listeria monocytogenes (Lm) is associated with adverse pregnancy outcomes. Infection occurs through consumption of contaminated food that is disseminated to the maternal-fetal interface. The influence on the gastrointestinal microbiome during Lm infection remains unexplored in pregnancy. The objective of this study was to determine the impact of listeriosis on the gut microbiota of pregnant macaques.

Methods

A non-human primate model of listeriosis in pregnancy has been previously described. Both pregnant and non-pregnant cynomolgus macaques were inoculated with Lm and bacteremia and fecal shedding were monitored for 14 days. Non-pregnant animal tissues were collected at necropsy to determine bacterial burden, and fecal samples from both pregnant and

SUBMITTER: Hugon AM 

PROVIDER: S-EPMC10651077 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature