Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic.

ABSTRACT: Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology for rapid acquisition of molecular fingerprints of TBI biochemistry to safely measure proxies for cerebral injury through the eye, providing a path toward noninvasive point-of-care neurodiagnostics using simultaneous Raman spectroscopy and fundus imaging of the neuroretina. Detection of endogenous neuromarkers in porcine eyes' posterior revealed enhancement of high-wave number bands, clearly distinguishing TBI and healthy cohorts, classified via artificial neural network algorithm for automated da

SUBMITTER: Banbury C 

PROVIDER: S-EPMC10651125 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature