Dually biofortified cisgenic tomatoes with increased flavonoids and branched-chain amino acids content.

ABSTRACT: Higher dietary intakes of flavonoids may have a beneficial role in cardiovascular disease prevention. Additionally, supplementation of branched-chain amino acids (BCAAs) in vegan diets can reduce risks associated to their deficiency, particularly in older adults, which can cause loss of skeletal muscle strength and mass. Most plant-derived foods contain only small amounts of BCAAs, and those plants with high levels of flavonoids are not eaten broadly. Here we describe the generation of metabolically engineered cisgenic tomatoes enriched in both flavonoids and BCAAs. In this approach, coding and regulatory DNA elements, all derived from the tomato genome, were combined to obtain a herbicide-resistant version of an acetolactate synthase (mSlALS) gene expressed broadly and a MYB12-like transc

SUBMITTER: Vazquez-Vilar M 

PROVIDER: S-EPMC10651156 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature