Randomized phase II trial evaluation of erectile function after attempted unilateral cavernous nerve-sparing retropubic radical prostatectomy with versus without unilateral sural nerve grafting for clinically localized prostate cancer.

ABSTRACT:

Background

Nonrandomized studies of unilateral nerve-sparing (UNS) radical prostatectomy (RP) have reported improved recovery of erectile function if the sacrificed cavernous nerve is reconstructed with a sural nerve graft (SNG).

Objective

To determine whether UNS RP plus SNG results in a 50% relative increase in potency at 2 yr compared to UNS RP alone.

Design, setting, and participants

The study enrolled patients from October 2001-May 2006 from a single academic center and was randomized, open label. Participants were men with localized prostate cancer recommended for UNS RP, less than 66 yr old, normal baseline erectile function, and willing to participate in early erectile dysfunction (ED) therapy. Patients were followed up to 2 yr.

Intervention

Patients un

SUBMITTER: Davis JW 

PROVIDER: S-EPMC10651170 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature