Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain.

ABSTRACT: Transcranial magnetic stimulation (TMS) has been used to examine inhibitory and facilitatory circuits during experimental pain and in chronic pain populations. However, current applications of TMS to pain have been restricted to measurements of motor evoked potentials (MEPs) from peripheral muscles. Here, TMS was combined with electroencephalography (EEG) to determine whether experimental pain could induce alterations in cortical inhibitory/facilitatory activity observed in TMS-evoked potentials (TEPs). In Experiment 1 (n=29), multiple sustained thermal stimuli were administered to the forearm, with the first, second, and third block of thermal stimuli consisting of warm but non-painful (pre-pain block), painful (pain block) and warm but non-painful (post-pain block) temperatures, respecti

SUBMITTER: Chowdhury NS 

PROVIDER: S-EPMC10651174 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature