Risk of stillbirth in United States patients with diagnosed intrahepatic cholestasis of pregnancy.

ABSTRACT:

Background

Intrahepatic cholestasis of pregnancy is associated with a 4- to 10-fold increase in the risk of stillbirth in the absence of intervention, leading to recommendations for antenatal assessment, ursodiol use, and often preterm or early term delivery.

Objective

This study aimed to determine whether current management strategies for intrahepatic cholestasis of pregnancy mitigate the elevated risk of stillbirth at a population level.

Study design

This was a retrospective cohort study using the 2015-2020 National Readmissions Database, an administrative database developed by the United States Agency for Healthcare Research and Quality. Our study identified delivery hospitalizations, gestational age at delivery, occurrence of intrahepatic cholestasis of pregnancy

SUBMITTER: Estin ML 

PROVIDER: S-EPMC10651178 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature