FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.

ABSTRACT:

Aims

Mitochondria play a vital role in cellular metabolism and energetics and support normal cardiac function. Disrupted mitochondrial function and homeostasis cause a variety of heart diseases. Fam210a (family with sequence similarity 210 member A), a novel mitochondrial gene, is identified as a hub gene in mouse cardiac remodelling by multi-omics studies. Human FAM210A mutations are associated with sarcopenia. However, the physiological role and molecular function of FAM210A remain elusive in the heart. We aim to determine the biological role and molecular mechanism of FAM210A in regulating mitochondrial function and cardiac health in vivo.

Methods and results

Tamoxifen-induced αMHCMCM-driven conditional knockout of Fam210a in the mouse cardiomyocytes induced progressive d

SUBMITTER: Wu J 

PROVIDER: S-EPMC10651191 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature